Red Amber List

Guidance in the Red / Amber List serves ONLY to define where clinical and prescribing responsibility for the listed medicines should lie in terms of governance and safety.

  • Inclusion in this list does NOT imply the medicine has been accepted for use via Managed Entry, does NOT imply endorsement of use, and does NOT take account of the cost implications of use of a particular medicine.
  • Prescribers should use this list in conjunction with guidance on the Managed entry process for medicines, and the NI formulary which includes information on current cost effective choices.
  • For information relating to the Local Enhanced Service (NILES) relating to Additional Monitoring of Amber Drugs click here
  • As far as possible, new specialist medicines are added to the list at the point when they are granted a UK product licence. In some instances this may be prior to the medicine being launched.

The table below lists specialist medicines. Users should search by generic name where possible. Brand names listed are not exhaustive.

Click to Show NEW entries only or limit alphabetically (by generic name):  A-B  C-D  E-J  K-M  N-R  S-Z

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Approved NameExample Trade NamesContextStatusGuidanceNew Entry
5 Aminolaevulinic acid gel Ameluz Red
Abatacept Orencia Red
Abiraterone Zytiga Red
Acitretin Neotigason Red
Adalimumab Humira Red
Adefovir Hepsera Red
Afamelanotide Scenesse Red
Afatinib Tomtovok Red
Aflibercept Eylea, Zaltrap. Red
Agomelatine Valdoxan Amber status only applies to cover the required monitoring during the first 24 weeks of treatment after which time the arrangement can be stepped down Amber Shared Care Guideline in development
Alectinib Alecensa Red
Alemtuzumab MabCampath, Lemtrada Red
Alipogene tiparvovec Glybera Red
Alirocumab Praluent Red
Alitretinoin Toctino Red
Alprostadil Caverject, MUSE, Viridal Duo, Vitaros Severe distress caused by impotence Red
Ambrisentan Volibris Red
Amifampridine Firdapse Red
Amiodarone Cordarone X Amber Amiodarone Shared Care Guideline
Anagrelide Xagrid Red
Anakinra Kineret Red
Anti-infectives IV Parenteral Anti-infectives Red
Antiretrovirals Red
Apomorphine APO-go Amber Apomorphine Shared Care Guideline
Apremilast Otezla Amber No Shared Care Guideline Required (Click for info)
Argatroban Exembol Red
Arsenic Trisenox Red
Asfotase alfa Strensiq Red
Ataluren Translarna Red
Atazanavir (with cobicistat) Evotaz Red
Atezolizumab Tecentriq Red
Atomoxetine Strattera Amber Atomoxetine Shared Care Guideline
Avanafil Spedra Erectile dysfunction, severe distress category only Red
Avelumab Bavencio Red
Axitinib Inlyta Red
Azacitadine Vidaza Red
Azathioprine Imuran Immunosuppressant post transplantation Amber Azathioprine Post Transplant Shared Care Guideline
Azathioprine Imuran Non transplant indications Amber Azathioprine (Other Non-Transplant Indications) Shared Care Guideline
Aztreonam (Inhaled) Cayston Inhaled for chronic pulmonary infections Red
Baricitinib Olumiant Red
Bedaquiline Sirturo Red
Belimumab Benlysta Red
Betaine Cystadane Amber GP Information sheet
Bevacizumab Avastin Red
Bexarotene Targretin Red
Bezlotoxumab Zinplava Red
Bicalutamide Casodex Amber No Shared Care Guideline Required (Click for info)
Bictegravir + emtricitabine + tenofovir alafenamide Biktarvy Red NEW
Blinatumomab Blincyto Red
Boceprevir Victrelis Red
Bortezomib Velcade Red
Bosentan Tracleer Red
Bosutinib Bosulif Red
Botulinum toxin type A and B various brands For all uses except cosmetic Red
Brentuximab Adcetris Red
Brodalumab Kyntheum Red
Bromelain Nexobrid Red
Buserelin Suprecur, Suprefact When used for treatment of infertility Red
Busulfan Myleran Red
C1 esterase inhibitor Cinryze, Berinert Red
Cabergoline Cabaser Amber Cabergoline Neurology Shared Care Guideline
Cabergoline Dostinex Amber Cabergoline Endocrinology Shared Care Guideline
Cabozantinib Cometriq Red
Canakinumab Ilaris Red
Cannabis buccal mucosal spray Sativex Red
CAPD Continuous Ambulatory Peritoneal Dialysis solutions Red
Capecitabine Xeloda Red
Capsaicin patch Qutenza Red
Carfilzomib Kyprolis Red
Ceritinib Zykadia Red
Certolizumab pegol Cimzia Red
Cetrorelix Cetrotide Red
Chlorambucil Leukeran Red
Chloroquine Nivaquine Non-malaria indications Amber No Shared Care Guideline Required (Click for info)
Choriogonadotropin Ovitrelle Infertility Red
Chorionic gonadotrophin Choragon, Pregnyl Infertility Red
Ciclosporin Neoral Non transplant indications Amber Ciclosporin (Non-Transplant Indications) Shared Care Guideline
Ciclosporin Neoral Immunosuppressant post transplantation Amber Ciclosporin Post Transplant Shared Care Guideline
Cinacalcet Mimpara Amber Cinacalcet Shared Care Guideline
Cladribine Mavenclad Multiple slerosis Red
Clomifene Clomid Amber Clomifene Shared Care Guideline
Clonidine ADHD and other behavioural and neurodevelopmental disorders Amber No Shared Care Guideline Required (Click for Info)
Clozapine Clozaril Red
Cobicistat Tybost Red
Cobimetinib Cotellic Red
Colistimethate sodium (Inhaled) Colomycin Amber Colistimethate Shared Care Guideline
Collagenase clostridium histolyticum Xiapex Red
Conestat alfa Ruconest Red
Crizotinib Xalkori Red
Cyclophosphamide When used as a systemic anti-cancer therapy Red
Cyclophosphamide (oral) Non-cancer indications Amber Cyclophosphamide Shared Care Guideline
Cytotoxics IV various examples Red
Dabrafenib Tafinlar Red
Daclatasvir Daklinza Red
Daclizumab Zinbryta Red
Dalteparin sodium Fragmin Amber Dalteparin Shared Care Guideline
Daratumumab Darzalex Red
Darbepoetin Aranesp Amber Local Arrangements For Shared Care May Apply (click for info)
Darunavir + cobicistat Rezolsta Red
Darunavir + cobicistat + emtricitabine + tenofovir alafenamide Symtuza Red
Dasatinib Sprycel Red
Deferasirox Exjade Red
Deferiprone Ferriprox Red
Defibrotide Defitelio Red
Delamanid Deltyba Red
Demeclocycline SIADH Amber Demeclocycline Shared Care Guideline
Denosumab Prolia Osteoporosis; treatment of bone loss associated with hormone ablation Amber Denosumab (Prolia) Shared Care Guideline
Denosumab Xgeva Bone metastases from solid tumours; giant cell tumour of bone Red
Desferrioxamine Desferal Chronic iron overload Amber No Shared care Guideline Required (Click for info)
Desferrioxamine Desferal Treatment of iron poisoning Red
Dexamethasone Implant Ozurdex Intravitreal injection route Red
Dexamfetamine Dexedrine Attention deficit hyperactivity disorder in adults and children 6 years and over, within NICE recommended doses, and for use in narcolepsy. Amber Dexamfetamine Shared care Guideline
Dexamfetamine Dexedrine Attention deficit hyperactivity disorder in children under 6 years, or doses over NICE recommended doses Red
Dimethyl fumarate Skilarence Psoriasis Amber Shared Care Guideline in development
Dimethyl Fumarate Tecfidera Multiple sclerosis Red
Dinutuximab Unituxin Red
Dolutegravir Tivicay Red
Dolutegravir + abacavir + lamivudine Triumeq Red
Dolutegravir + rilpivirine Juluca Red NEW
Donepezil Aricept Amber No Shared Care Guideline required (Click for info)
Dornase alfa Pulmozyme Amber No Shared Care guideline required (Click for info)
Dronedarone Multaq Amber Dronedarone Shared Care Guideline
Dupilumab Dupixent Red
Eculizumab Soliris Red
Eliglustat Cerdelga Red
Elosulfase alfa Vimizim Red
Elotuzumab Empliciti Red
Eltrombopag Revolade Red
Elvitegravir Vitekta Red
Emtricitabine + tenofovir alafenamide Descovy Red
Emtricitabine, tenofovir, elvitegravir, cobicistat Stribild Red
Enoxaparin Clexane Amber Enoxaparin Shared Care Guideline
Entecavir Baraclude Red
Enzalutamide Xtandi Red
Epoetin Eprex, NeoRecormon Amber Local Arrangements For Shared Care May Apply
Epoprostenol Flolan Red
Eribulin Halaven Red
Erlotinib Tarceva Red
Estramustine Estracyt Red
Etanercept Enbrel Red
Etelcalcetide Parsabiv Red
Etoposide Vepesid Red
Everolimus Certican Post-transplant immunosuppressant Amber No Shared Care Guideline Required (Click for info)
Everolimus Afinitor, Votubia When used as a systemic anti-cancer therapy or for manifestations of tuberous sclerosis complex Red
Evolocumab Repatha Amber GP Information sheet
Fampridine Fampyra Red
Filgrastim Neupogen, Accofil, Zarzio Red
Fingolimod Gilenya Red
Fludarabine Fludara Red
Fluocinolone Intravitreal Implant Iluvien Red
Flutamide Drogenil Amber No Shared Care Guideline Required (Click for info)
Follitropin alfa, beta & delta Gonal-F, Puregon, Ovaleap, Bemfola, Pergoveris, Rekovelle Infertility Red
Galantamine Reminyl Amber No Shared Care Guideline Required (Click for info)
Galsulfase Naglazyme Red
Ganciclovir IV Cymevene Red
Ganirelix Orgalutran Infertility Red
Gefitinib Iressa Red
Gemtuzumab Mylotarg Red
Glatiramer acetate Copaxone Red
Glecaprevir + pibrentasvir Maviret Red
Glycerol phenylbutyrate Ravicti Amber GP Information Sheet
Golimumab Simponi Red
Gonadorelin analogues Suprecur, Suprefact, Prostap, Zoladex, Synarel, Decapeptyl When used for treatment of infertility. Red
Goserelin Zoladex When used for treatment of infertility Red
Grass pollen extract Grazax Amber No Shared Care Guideline required (Click for info)
Grazoprevir + elbasvir Zepatier Antiretroviral Red
Guanfacine Intuniv Amber Guanfacine Shared Care Guideline
Guselkumab Tremfya Red
Human alpha1-proteinase inhibitor Respreeza Red
Human menopausal gonadotrophins Menogon, Menopur Infertility Red
Hydroxycarbamide Hydrea Myeloproliferative disorders and other non-cancer indications. Amber Hydroxycarbamide Shared Care Guideline
Hydroxycarbamide Hydrea When used as a systemic anti cancer therapy Red
Hydroxychloroquine Plaquenil Amber Hydroxychloroquine Shared Care Guideline
Ibandronate IV injection Bonviva Red
Ibrutinib Imbruvica Red
Icatibant Firazyr Red
Idarubicin Zavedos Red
Idebenone Raxone Leber's Hereditary Optic Neuropathy Red
Idelalisib Zydelig Red
Idursulfase Elaprase Red
Iloprost Ilomedin, Ventavis Red
Imatinib Glivec Red
Imiglucerase Cerezyme Red
Immunoglobulin Cuvitru, Gammabulin, Gammagard, Kabiglobulin, Flebogamma, Sandoglobulin, Subcuvia, Vigam Specialist indications Red
Infliximab Remicade Red
Inotuzumab ozogamicin Besponsa Red
Interferon alfa Intron-A, Roferon-A Red
Interferon alfa Roferon-A, Viraferon Red
Interferon beta-1a Avonex, Rebif Red
Interferon beta-1b Betaferon Red
Interferon gamma Immukin Red
Ipilimumab Yervoy Red
Irinotecan Red
Iron (Parenteral) Monofer, Cosmofer, Venofer, Ferinject, Rienso Red
Isavuconazole Cresemba Red
Isocarboxazid Isocarboxazid Amber No Shared Care Guideline Required (Click for info)
Isotretinoin Roaccutane Red
Ivabradine Procoralan Chronic heart failure NYHA class II to IV Amber No Shared Care Guideline Required (Click for info)
Ivacaftor Kalydeco Red
Ixazomib Ninlaro Red
Ixekizumab Taltz Red
Ketamine Ketalar, Ketamine oral solution Palliative Care (outside licence) Amber Ketamine Shared Care Guideline
Ketamine Ketalar, Ketamine oral solution Neuropathic pain Red
Ketanserin Sufrexal Red
Ketoconazole HRA Ketoconazole HRA HRA formulation (for Cushing's syndrome) only Red
L-Tryptophan Optimax Amber No Shared Care Guideline Required (Click for info)
Lamivudine Zeffix Red
Lanreotide Somatuline Neuroendocrine tumours and acromegaly. Within licence Amber Lanreotide Shared Care Guideline
Lanreotide Somatuline Outside licence Red
Lapatinib Tyverb Red
Leflunomide Arava Amber Leflunomide Shared Care Guideline
Lenalidomide Revlimid Red
Lenograstim Granocyte Red
Lenvatinib Lenvima Red
Leuprorelin Prostap, Lutrate When used for treatment of infertility Red
Levofloxacin nebuliser solution Quinsair Red
Linezolid Zyvox Red
Liothyronine Management of thyroid disorders Amber Liothyronine Shared Care Guideline
Lipegfilgrastim Lonquex Red
Lisdexamfetamine Elvanse Amber Lisdexamfetamine Shared Care Guideline
Lithium Camcolit, Liskonum, Priadel Amber Lithium Shared Care Guideline
Lofexidine BritLofex Red
Lomitapide Lojuxta Red
Lomustine Red
Lumacaftor (with ivacaftor) Orkambi Red
Lutetium(177Lu) oxodotreotide Lutathera Red
Lutropin Luveris, Pergoveris Red
Macitentan Opsumit Red
Mecasermin Increlex Red
Melatonin Amber Melatonin Shared Care Guideline
Melphalan Alkeran Red
Memantine Ebixa Amber No Shared Care Guideline Required (Click for info)
Mepolizumab Nucala Red
Mercaptopurine Puri-Nethol For non-cancer indications Amber Mercaptopurine Shared Care Guideline
Mercaptopurine Puri Nethol When used as a systemic anti-cancer therapy Red
Methotrexate oral For non-cancer indications Amber Methotrexate oral Shared Care Guideline
Methotrexate Subcutaneous (Metoject) For non-cancer indications Amber Methotrexate subcutaneous Shared Care Guideline
Methotrexate oral When used as a systemic anti-cancer therapy Red
Methotrexate parenteral (other than subcutaneous) All indications Red
Methyl aminolevulinate cream Metvix Red
Methylphenidate Ritalin, Equasym, Concerta XL, Delmosart For attention deficit hyperactivity disorder in adults and children 6 years and over, within NICE recommended doses. Amber Methylphenidate Shared Care Guideline
Methylphenidate Ritalin, Equasym, Concerta XL, Delmosart For attention deficit hyperactivity disorder in children under 6 years, or doses over NICE recommended doses. Red
Midostaurin Red
Migalastat Galfold Red
Miglustat Zavesca Red
Mitotane Lysodren Red
Moclobemide Manerix Amber No Shared Care Guideline Required (Click for info)
Modafinil Provigil Amber No Shared Care Guideline required - GP Information sheet
Mycophenolate mofetil CellCept Immunosuppressant post transplantation Amber Mycophenolate mofetil Post Transplant Shared Care Guideline
Mycophenolate mofetil CellCept Non transplant indications Amber Mycophenolate mofetil (other non-transplant indications) shared care guideline
Nabilone Red
Nafarelin Synarel When used for treatment of infertility Red
Naltrexone Nalorex Amber No Shared Care Guideline Required (Click for info)
Natalizumab Tysabri Red
Necitumumab Portrazza Red
Nilotinib Tasigna Red
Nintedanib Vargatef , Ofev Red
Niraparib Zejula Red
Nivolumab Opdivo Red
Nusinersen Spinraza Red
Obinutuzumab Gazyvaro Red
Ocrelizumab Ocrevus Red
Ocriplasmin Jetrea Red
Octreotide Sandostatin Palliative Care Amber Octreotide Palliative Care Shared Care Guideline
Octreotide Sandostatin Neuroendocrine tumours and acromegaly. Within licence. Amber Octreotide Endocrinology Shared Care Guideline
Octreotide Sandostatin Outside licence (except Palliative Care) Red
Ofatumumab Arzerra Red
Olanzapine Long Acting Injection Zypadhera Red
Olaparib Lynparza Red
Olaratumab Red
Omalizumab Xolair Red
Osimertinib Tagrisso Red
Padeliporfin Tookad Red
Palbociclib Ibrance Red
Palivizumab Synagis Red
Pamidronate Disodium Aredia Red
Panobinostat Farydak Red
Parathyroid hormone subcutaneous injection Preotact Osteoporosis Red
Paritaprevir + ritonavir + ombitasvir Viekirax Red
Paritaprevir + ritonavir + ombitasvir +/- dasabuvir Red
Pasireotide Signifor Red
Pazopanib Votrient Red
Pegaspargase Oncaspar Red
Pegfilgrastim Neulasta Red
Peginterferon alfa PegIntron, ViraferonPeg, Pegasys Red
Peginterferon beta-1a Plegridy Red
Pegloticase Krystexxa Red
Pegvisomant Somavert Red
Pembrolizumab Kytruda Red
Penicillamine Distamine Amber Penicillamine Shared Care Guideline
Pentosan polysulfate sodium Red
Pergolide Celance Amber Pergolide Shared Care Guideline
Pertuzumab Perjeta Red
Phenelzine Nardil Amber No Shared Care Guideline Required (Click for info)
Phenylbutazone Butacote Red
Pirfenidone Esbriet Red
Pixantrone Pixuvri Red
Plerixafor Mozobil Red
Pomalidomide Imnovid Red
Ponatinib Iclusig Red
Posaconazole Noxafil Red
Procarbazine Red
Radium Xofigo Red
Raltegravir Isentress Red
Raltegravir + lamivudine Dutrebis Red
Ramucirumab Cyramza Red
Ranibizumab Lucentis Red
Regorafenib Stivarga Red
Reslizumab Cinqaero Red
Ribavirin Rebetol, Virazole, Copegus Red
Ribociclib Kisqali Red
Riluzole Rilutek Motor neurone disease. Supply will remain via secondary care Amber Riluzole Shared Care Guideline
Riociguat Adempas Red
Rituximab MabThera Red
Rivastigmine Exelon Amber No Shared Care Guideline Required (Click for info)
Romiplostim injection Nplate Red
Ruxolitinib Jakavi Red
Sapropterin Kuvan Red
Sarilumab Kevzara Red
Sebelipase alfa Kanuma Red
Secukinumab Cosentyx Red
Selexipag Uptravi Red
Sildenafil Revatio Pulmonary arterial hypertension Amber Sildenafil Shared Care Guideline
Sildenafil Viagra Severe distress caused by impotence Red
Siltuximab Sylvant Red
Simeprevir Olysio Red
Sirolimus Rapamune Amber Sirolimus Shared Care Guideline
Sodium aurothiomalate Myocrisin Amber Sodium Aurothiomalate Shared Care Guideline
Sodium clodronate Bonefos IV only; hypercalcaemia of malignancy Red
Sodium oxybate Xyrem Red
Sodium phenylbutyrate Ammonaps Amber GP Information Sheet
Sofosbuvir Solvadi Red
Sofosbuvir + ledipasvir Harvoni Red
Sofosbuvir + velpatasvir Epclusa Antiretroviral Red
Somatropin Genotropin, Norditropin, Humatrope, Saizen, Zomacton Amber Somatropin Shared Care Guideline
Sonidegib Odomzo Red
Sorafenib Nexavar Red
Stiripentol Diacomit Amber GP Information sheet
Sulfasalazine Salazopyrin Amber Sulfasalazine Shared Care Guideline
Sunitinib Sutent Red
Tacrolimus Prograf Immunosuppressant post transplantation Amber Tacrolimus Post Transplant Shared Care Guideline
Tacrolimus Prograf Inflammatory eye disease Amber Tacrolimus Ophthalmology Shared Care Guideline
Tadalafil Adcirca Pulmonary arterial hypertension Amber Tadalafil Shared Care Guideline
Tadalafil Cialis Severe distress caused by impotence Red
Tafamidis Vyndaqel Red
Talimogene laherparepvec Imlygic Red
Tedizolid Sivextro Red
Teduglutide Revestive Red
Tegafur with gimeracil and oteracil Teysuno Red
Tegafur with uracil Uftoral Red
Teicoplanin Targocid Red
Telaprevir Incivo Red
Telbivudine Sebivo Red
Temozolomide Temodal Red
Tenofovir Viread Red
Tenofovir, alafenamide, elvitegravir, cobicistat + emtricitabine Genvoya Red
Teriflunomide Aubagio Red
Teriparatide Forsteo Red
Testosterone Amber Testosterone Shared Care Guideline
Thalidomide Pharmion Red
Thioridazine Red
Tinzaparin Sodium Innohep Amber No Shared Care Guideline Required (Click for info)
Tioguanine Lanvis Red
Tipiracil + trifluridine Lonsurf Red
Tobramycin Tobi, Nebcin IV or nebulised Red
Tocilizumab RoActemra Red
Tofacitinib Xeljanz Red
Tolcapone Tasmar Amber Tolcapone Shared Care Guideline
Tolvaptan Samsca, Jinarc Red
Topotecan Hycamtin Red
Total Parenteral Nutrition (TPN Solutions) Red
Trametinib Mekinist Red
Tranylcypromine Amber No Shared Care Guideline Required (Click for info)
Trastuzumab Herceptin, including Herceptin SC Red
Trastuzumab emtansine Kadcyla Red
Treosulfan Red
Treprostinil Red
Tretinoin Vesanoid Red
Trientine Amber No Shared Care Guideline required - GP Information sheet
Triptorelin Decapeptyl, Gonapeptyl, Salvacyl When used for treatment of infertility Red
Ustekinumab Stelara Red
Valganciclovir Valcyte Red
Vandetanib Caprelsa Red
Vardenafil Levitra Severe distress caused by impotence Red
Vedolizumab Entyvio Red
Velaglucerase alfa VPRIV Red
Vemurafenib Zelboraf Red
Venetoclax Venclyxto Red
Venlafaxine Efexor Only considered specialist medicine (Amber category) at doses greater than 300mg daily Amber No Shared Care Guideline Required (Click for info)
Vinorelbine Navelbine Red
Vismodegib Erivedge Red
Voriconazole Vfend Red
Warfarin Amber sub-group Local Arrangements For Shared Care May Apply
Zoledronic acid Aclasta, Zometa Red

You can also Download the Red Amber List as a CSV file